... Now, Deadpool can get drunk. The only way to kill you permanently is to destroy you entirely. Deadpool: You are an interesting problem, Doomsday. Where Superman refuses to kill, that is all Deadpool … Not only that, but every time somebody kills you, you just come back immune to whatever killed you before. I just don't think he has the intelligence to lay a good enough trap to beat and or kill Superman. Just because he has a healing factor doesn't mean he can't lose; it simply means his opponent has to get creative to find a way to keep him down. One of the main reasons that the Merc with a Mouth is so lethal is because he’s dedicated to killing his targets. Superman is the most overpowered of ALL comic book hero's and as for Deadpool he isn't immortal he can die. Superman is the typical hero, and Batman is more the antihero type. But traditionally even Batman was still a hero who didn’t kill indiscriminately. Marvel have just announced "The Death of Deadpool". If anyone can kill off Deadpool it's marvel. Deadpool's morality has shifted over the years for Deadpool, with the Merc with a Mouth transforming from a villain to a hero over the years. But that’s the beauty of Deadpool as he is very unpredictable, we know that he has stunning kill list on his name, and had killed the whole of Marvel universe in an alternate reality so Deadpool could beat Superman with ease. This includes some notoriously hard to kill characters like the Hulk, Wolverine, Luke Cage, and the rest of the Avengers and the X-Men. During that comic's first arc, "If Looks Could Kill," the titular heroes are infected by the Facade Virus, a disease that allows victims to change their faces. Deadpool was his most heroic when he briefly served as an Avenger -- before a choice to follow the orders of Captain America during Secret Empire cost him everything. Even if Bane can't punch deadpool out he can still put him into a submission hold or something along those lines which would count as incapacitation. Supes looks at Deadpool and his Swords or Guns chuckles a bit then throws him into space. Deadpool Annual #1 It’s kind of hard to call wrong place, wrong time in comics’ most superhero dense city, but such is the way of Deadpool’s run in with Thor. Marvel Comics has announced, via Nerdist, that they will be killing Deadpool in April's Deadpool #250, which will be the final issue of his ongoing series. Likewise, when it comes to comic books, there always has been a range of superheroes. We've already talked about the superheroes Deadpool has beaten, many of whom were courtesy of Deadpool's killing spree against the Marvel universe. The only thing that has ever killed Superman. Even Jesus can be seen as a kind of outlaw, in that He came into conflict with a corrupt legal system. 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